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KMID : 1161420200230030305
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Journal of Medicinal Food
2020 Volume.23 No. 3 p.305 ~ p.311
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Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model
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Ramirez-Higuera Abril
Pena-Montes Carolina
Herrera-Meza Socorro
Mendoza-Lopez Remedios
Valerio-Alfaro Gerardo
Oliart-Ros Rosa Maria
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Abstract
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The metabolic syndrome (MS) underlies metabolic disorders considered risk factors for the development of diabetes and cardiovascular diseases, which are major causes of morbidity and mortality in most of the world. Sterculic acid has been proposed as a potential tool for the treatment of MS since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1), a central enzyme in lipid metabolism. We analyzed the effect of sterculic oil (SO) co-administration with 30% fructose in drinking water on the development of MS in male Wistar rats. After 8 weeks, 0.4% SO exerted a protective effect from MS development since parameters altered by fructose (blood pressure, insulin resistance, serum glucose and triglycerides, steatosis, and adiposity) were similar to those of control rats.
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KEYWORD
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cyclopropene fatty acids, fructose-induced model, metabolic syndrome, stearoyl-CoA desaturase, Sterculia apetala, sterculic oil
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